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2010年

  • Immunogenicity of Whole-Parasite Vaccines against Plasmodium falciparum Involves Malarial Hemozoin and Host TLR9. Cevayir Coban, Yoshikatsu Igari, Masanori Yagi, Thornik Reimer, Shohei Koyama, Taiki Aoshi, Keiichi Ohata, Toshihiro Tsukui, Fumihiko Takeshita, Kazuo Sakurai, Takahisa Ikegami, Atsushi Nakagawa, Toshihiro Horii, Gabriel Nunez, Ken J. Ishii, and Shizuo Akira1. Cell Host & Microbe. Volume7, Issue 1, 50-61, (2010)

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  • Encapsulation of a Hydrophobic Drug into a Polymer-Micelle Core Explored with Synchrotron SAXS. Akiba, I.; Terada, N.; Hashida, S.; Sakurai, K.; Sato, T.; Shiraishi, K.; Yokoyama, M.; Masunaga, H.; Ogawa, H.; Ito, K.; Yagi, N. Langmuir, 26, 7544-7551(2010)　 DOI: 10.1021/la904355p

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  • Cation-specific Transition from Vesicle to Lamella for an Aromatic Diamine Lipid in Aqueous Solutions. Tomoki Nishimura, Hiroyasu Masunaga, Hiroki Ogawa, Isamu Akiba and Kazuo Sakurai. Chemistry Letters. Vol. 39  , No. 7 p.686 (2010)　 doi:10.1246/cl.2010.686

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  • Plasmacytoid Dendritic Cells Delineate Immunogenicity of Influenza Vaccine Subtypes. Shohei Koyama, Taiki Aoshi, Takeshi Tanimoto, Yutaro Kumagai, Kouji Kobiyama, Takahiro Tougan, Kazuo Sakurai, Cevayir Coban1, Toshihiro Horii, Shizuo Akira, and Ken J. Ishii. Science, Transl. Med 3 25 (2010)

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  • Flexibility and Local Structure of the Wormlike Cylinder in the Organogel of Self-Assembled Discotic Triazine Triamide. Yasuya Kudo ,Mina Sakuragi , Satoshi Hashida , Tsutomu Ishii , Hiroyasu Masunaga, Kazuo Sakurai. Polymer Journal. doi:10.1038/pj.2010.72

 

  • Synthesis of a Highly Hydrophobic Cationic Lipid and its Structural and Thermodynamic Studies for Interaction with DNA. Tomoki Nishimura, Takeshi Cho, Andrew M. Kelley, Magdalena E. Powell, John S. Fossey, Steven D. Bull, Tony D. James, Hiroyasu Masunaga, Isamu Akiba, Kazuo Sakurai. Vol. 83 (9), 1010-1018, Bulletin of the Chemical Society of Japan.　 doi:10.1246/bcsj.20100072

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  • b-1,3-glucan/Antisense Oligonucleotide Complex Stabilized with Phosphorothioation and its Gene Suppression. Shinichi Mochizuki and Kazuo Sakurai. Bioorganic Chemistry Vol. 38. P260-264 (2010)　 doi:10.1016/j.bioorg.2010.07.001

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  • Self-Assembled Synthetic Viral Capsids from a 24-mer Viral Peptide Fragment. Matsuura, Kazunori; Watanabe, Kenta; Matsuzaki, Tsubasa; Sakurai, Kazuo; Kimizuka, Nobuo. Angewandte Chem. 49. P9662-9665, (2010). DOI: 10.1002/ange.201004606

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  • Self-Assembly of Amphiphilic Block Copolymers Containing Poly(n-octadecyl acrylate) Block in Aqueous Solution. Isamu Akiba, Yusuke Akino, Hiroyasu Masunaga and Kazuo Sakurai. Mater. Sci. Eng. 14 012009 (2010).　 doi: 10.1088/1757-899X/14/1/012009

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2009年

  • Flexibility and Cross-Sectional Structure of an Anionic Dual-Surfactant Wormlike Micelle Explored with Small-Angle X-Ray Scattering Coupled with Contrast Variation Technique. Kenzo Naruse, Kenichi Eguchi, Isamu Akiba, Kazuo Sakurai, Hiroyasu Masunaga, Hiroki Ogawa, and John S. Fossey. The Journal of Physical Chemistry B, 113 (30), 10222–10229 (2009)

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  • Supramolecular Structures of Benzyl Amine Derivate/DNA Complexes Explored with Synchrotron Small Angle X-ray Scattering at SPring-8. Mina Sakuragi, Shouta Kusuki, Emi Hamada, Hiroyasu Masunaga, Hiroki Ogawa, Isamu Akiba, and Kazuo Sakurai. Journal of Physics (Conference Series for IUMRS-ICA 2008), 184, 012008 (2009)

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  • A Novel Polysaccharide/Polynucleotide Complex and its Application to Bio-functional DNA Delivery System. Shinichi Mochizuki and Kazuo Sakurai. Polymer Journal, vol.41, 343-353 No.5 (2009) (Award account)

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  • Octadecylsilyl silica column method for extraction of messenger RNA. Taro Kimura, Kazuo Sakurai, and Seiji Shinkai. Analytical Biochemistry, 391, 72-73 (2009)

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  • Antisense Oligonucleotides Delivery to the Antigen Presenting Cells by using Schizophyllan. Shinichi Mochizuki, Jusaku Minari and Kazuo Sakurai. MRS Fall Meeting Symposium HH (in press).

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  • 「ポリカチオンに誘起された5'-GMP希薄溶液からのG-ワイアーの形成」上原周一朗、櫻木美菜、櫻井和朗　高分子論文集 66, 179 (2009)

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  • 「カチオン性ミセルとDNAが形成する超分子構造と遺伝子導入効率の関係」櫻木　美菜、楠木　翔太、濱田　衣美増永　啓康、佐々木　園、櫻井　和朗　高分子論文集 66, 211 (2009)

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  • Synthesis of calcium phosphate-binding liposome for drug delivery. Takahisa Anada, Yoichi Takeda, Yoshitomo Honda, Kazuo Sakurai, and Osamu Suzuki. Bioorganic & Medicinal Chemistry Letters, 19 (15), 4148-4150 (2009).

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2008年

  • Polysaccharide-Templated Twisted Assemble of 2-Anilinonaphthalene-6-Sulfonic Acid. Naohiko Shimada, Tadashi Okobira, Yoichi Takeda, Seiji Shinkai, Kazuo Sakurai. J. Polymer Science Part A;46,1440-1448 (2008).

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  • Clustered CpG Sequences to Enhance Cytokine Secretion from Macrophages.  Jusaku Minari, Naohiko Shimada, and Kazuo Sakurai Chemistry Letters;37(1)，92-93 (2008).

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  • Intramolecular Cation–π Interactions Control the Conformation of Nonrestricted (Phenylalkyl)Pyridinesw. Isabella Richter, Jusaku Minari, Philip Axe, John P. Lowe, Tony D. James, Kazuo Sakurai, Steven D. Bull and John S. Fossey. ChemComm. 1082 – 1084 (2008).

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  • Molecular Dynamics Studies of Side Chain Effect on the β-1,3-D-Glucan Triple Helix in Aqueous Solution. Okobira, T.; Miyoshi, K.; Uezu, K.; Sakurai, K.; Shinkai, S. Biomacromolecules; 9(3); 783-788 (2008).

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  • Entrapment of Immature Amyloid Protofilaments in the Hydrophobic Domain of Schizophyllan. Sakuragi, M.; Takeda, Y.; Shimada, N.; Sakurai, K.; Polymer Bulletin; 1(61); 107-117 (2008).

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  • 3’ Poly(dA)-Tailed Thrombin DNA Aptamer to Increase DNase-Resistance and Clotting Inhibitory Activity. Shuichiro Uehara1, Naohiko Shimada, Yoichi Takeda, Yoshikazu Koyama,Yoshifumi Takei, Hironori Ando, Susumu Satoh, Atsushi Uno, and Kazuo Sakurai; Bull. Chem. Soc. Jpn.;81(11) ;1485-1491 (2008)，

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  • Enhanced Cytokine Secretion Owing to Multiple CpG Side Chains of DNA Duplex. Jusaku Minari, Shinich Motizuki, and Kazuo Sakura. Oligonucleotides.; 18(4); 337-344 (2008)

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  • Amidine-Bearing lipoplex targeting to hepatocyte cells. Yasuya Kudoa, Kazunori Koiwaib, Kazuhiro Shimizub, Shota Kusukia, Mina Sakuragia, Naohiko Shimadaa, Yoichi Takedaa and Kazuo Sakurai Chinese Chemical Letters. Volume 19, Issue 9, September 2008, Pages 1115-1118

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  • Solid State Structures and Solution Analyses of a Phenylpropylpyridine N-Oxide and an N-Methyl Phenylpropylpyridine Isabella Richter, Mark R. Warren, Jusaku Minari, Souad A. Elfeky, Wenbo Chen, Mary F. Mahon, Paul R. Raithby, Tony D. James, Kazuo Sakurai, Simon J. Teat, Steven D. Bull and John S. Fossey Chemistry Asian Journal ;4,194-198(2008)

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2007年

  • Complex Made from Tetrasodium N,N-Bis(carboxymethyl) Glutamate Salt and Sodium Oleate that Forms a Highly Ordered Lamella in Gel Phase. Jeong, Y., Uezu. K., Sakurai, S., Masunaga, H., Inoue, K., Sasaki, S., Shimada, N., Takeda, Y., Kaneko, K. and Sakurai, K. Bull. Chem. Soc. Jpn.; 80(2), 410-417 (2007).

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  • Ternary Complex Consisting of DNA, Polycation, and a Natural Polysaccharide of Schizophyllan to Induce Cellular Uptake by Antigen Presenting Cells. Yoichi Takeda, Naohiko Shimada, Kenji Kaneko, Seiji Shinkai, and Kazuo Sakurai. Biomacromolecules; 2(3), 1178-1186 (2007).

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  • DNA Conformational Switching by Use of an Intercalator and Its Receptor. Tomoki Nishimura, Yoichi Takeda, Naohiko Shimada, and Kazuo Sakurai1. Chemistry Letters; 36( 3 )388-389 (2007).

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  • Instantaneous Inclusion of a Polynucleotide and Hydrophobic Guest Molecules into a Helical Core of Cationic -1,3-Glucan Polysaccharide. Ikeda, M.; Hasegawa, T.; Numata, M.; Sugikawa, K.; Sakurai, K.; Fujiki, M.; Shinkai, S.  J. Am. Chem. Soc.; 129(13), 3979-3988 (2007)

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  • Salt-Concentration Dependence of the Structure and Form Factors for the Wormlike-Micelle Made from LES/AMPB Dual-Surfactant in Aqueous Solution. Kenichi Eguchi, Isamu Kaneda, Yoshiko Hiwatari, Hiroyasu Masunagac and Kazuo Sakurai. J. Applied Crystallography; 40, 264–268 (2007).

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  • A Polysaccharide Carrier to Effectively Deliver Native Phosphodiester CpG DNA to Antigen-Presenting-Cells. Naohiko Shimada, Cevayir Coban, Yoichi Takeda, Masami Mizu, Jusaku Minari, Takahisa Anada, ,Yuichi Torii, Seiji Shinkai, Shizuo Akira, Ken J. Ishii, Kazuo Sakurai. Bioconjugate Chem. 1136-1140 (2007)

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  • Delivery of Antisense Oligonucleotides to Nuclear Telomere RNA by Use of a Complex between Polysaccharide and Polynucleotide. Jusaku Minari, Takanori Kubo, Hideki Ohba, Naohiko Shimada, Yoich Takeda, Ryouji Karinaga, Takahisa Anada, Kazuya Koumoto, Takeshi Kawazu, Takeshi Nagasaki, Seiji Shinkai, and Kazuo Sakurai. Bull. Chem. Soc. Jpn.; 80(6), 1091-1098 (2007).

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  • DNA Binding of Tilorone; 1H NMR and Calorimetric Studies of the Intercalation. Tomoki Nishimura, Tadashio Okobira, Andrew M. Kelly, Naohiko Shimada, Yoichi Takeda, and Kazuo Sakurai. Biochemistry;46(27), 8156 -8163 ,(2007).

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  • Complex Formathion between Cationic β-1,3-Giukan and Hetero-Sequence Oligodeoxynucleotide and        Its Delivery into Macrophage-Like Cell to Induce Cytokine Secretion. M.Ikeda, J.Minari, N.Shimada, M.Numata, K.Sakurai, and S.shinkai.Org.Biomol.chem;5,2219-2224,(2007)

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2006年

  • An enantiomeric nanoscale architecture obtained from a pseudoenantiomeric aggregate: Covalent fixation of helical chirality formed in Self-Assembled discotic triazine triamides by chiral amplification. Ishi-I, Tsutomu; Kuwahara, Rempei; Takata, Akihiko; Jeong, Yeonhwan; Sakurai, Kazuo; Mataka, Shuntaro.  Chemistry European Journal (2006), 12(3), 763-776.

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  • Click Chemistry on Curdlan: A Regioselective and Quantitative Approach to Develop Artificial β-1,3-Glucans with Various Functional Appendages. Hasegawa, Teruaki; Umeda, Mariko; Numata, Munenori; Fujisawa, Tomohisa; Haraguchi, Shuichi; Sakurai, Kazuo; Shinkai, Seiji. Chemistry Letters  (2006), 35(1), 82-83.

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  • Galactose-PEG dual Conjugation of B-(1→3)-D-Glucan Schizophyllan for Antisense Oligonucleotides Delivery to Enhance The Cellular Uptake. Karinaga, Ryouji; Anada, Takahisa; Minari, Jusaku; Mizu, Masami; Koumoto, Kazuya; Fukuda, Junji; Nakazawa, Kohji; Hasegawa, Teruaki; Numata, Munenori; Shinkai, Seiji; Sakurai, Kazuo. Biomaterials 27(8), 1626-1635, (2006).

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  • CpG DNA/Zymosan Complex to Enhance Cytokine Secretion Owing to The Cocktail Effect. Anada, Takahisa; Okada, Naoko; Minari, Jusaku; Karinaga, Ryouji; Mizu, Masami; Koumoto, Kazuya; Shinkai, Seiji; Sakurai, Kazuo. Bioorganic & Medicinal Chemistry Letters 16(5), 1301-1304, (2006).

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  • 計算化学を用いた多糖/核酸複合体の構造検討 三好賢太郎、上江洲一也、櫻井和朗、新海征治 高分子論文集 63(.7)、451-457（2006）

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  • 多糖・核酸複合体を利用したアンチセンスDNAの肝細胞への効果的なデリバリー 狩長亮二、三成寿作、櫻井和朗、新海征治 高分子論文集 63(.7)、468-475（2006）

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  • Polyrotaxane/DNA Conjugate by Use of Intercalation; Bridge Formation between DNA Double Helices.Kenji Tokuhsia, Emi Hamada, Ryouji Karinaga,Naohiko Shimada,Yoichi Takeda, Shinichi Kawasaki, and Kazuo Sakurai Macromolecules. 9480-9485 (2006)

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  • Synthesis and in Vitro Characterization of Antigen-Conjugated Polysaccharide as a CPG DNA Carrier. Shimada, N.; Ishii, K. J.; Takeda, Y.; Coban, C.; Torii, Y.; Shinkai, S.; Akira, S.; Sakurai, Kazuo　Bioconjug Chem (2006), 17, (5), 1136-1140.

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  • Encapsulation of Ferricytochrome c into the Nanoparticle Made from a Natural Polysaccharide:  Schizophyllan. Kasuga, Mika; Shimada, Naohiko; Takeda, Yoichi; Shinkai, Seiji; Sakurai, Kazuo. Chemistry Letters (2006), 35(1), 1120-1121.

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  • Galactose-PEG dual Conjugation of β-(1→3)-D-Glucan Schizophyllan for Antisense Oligonucleotides Delivery to Enhance the Cellular Uptake．Karinaga, Ryouji; Anada, Takahisa; Minari, Jusaku; Mizu, Masami; Koumoto, Kazuya; Fukuda, Junji; Nakazawa, Kohji; Hasegawa, Teruaki; Numata, Munenori; Shinkai, Seiji; Sakurai, Kazuo.　Biomaterials 27(8), 1626-1635(2006)

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2005年

  • β-1,3-Glucan (Schizophyllan) Can Act as a One-Dimensional  Host for Creation of Novel Poly(aniline) Nanofiber Structures. Munenori Numata, Teruaki Hasegawa, Tomohisa Fujisawa, Kazuo Sakurai and Seiji Shinkai. Org. Lett., 6(24), 4447-4450,(2005)

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  • Schizophyllans Carrying Oligosaccharide-Appendages as Potential Candidates for Cell-Targeted Antisense Carrier. Teruaki Hasegawa, Tomohisa Fujisawa, Munenori Numata, Takahiro Matsumoto, Mariko Umeda, Ryouji Karinaga, Masami Mizu, Kazuya Koumoto, Taro Kimura, Shiro Okumura, Kazuo Sakurai and Seiji Shinkai. Organic and biomolecular chemistry, 2, 3091-3098(2004)

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  • Proposal of New Modification Technique for Linear Double-Stranded DNAs Using the Polysaccharide Schizopyllan. Takahisa Anada, Hideshi Matsunaga, Ryouji Karinaga, Kazuya Koumoto, Masami Mizu, Koji Nakano, Seiji Shinkai and Kazuo Sakurai. Bioorganic & Medicinal Chemistry Letters, 14, (2004),5655-5659

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  • Single-Walled Carbon Nanotubes Acquire a Specific Lectin-Affinity through Supramolecular Wrapping with Lactose-Appended Schizophyllan. Teruaki Hasegawa, Tomohisa Fujisawa, Munenori Numata, Mariko Umeda, Takahiro Matsumoto, Taro Kimura, Shiro Okumura, Kazuo Sakurai and Seiji Shinkai. Chem. Commun, 2150-2151,(2004)

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  • Rod-Like Architecture and Helicity of the Poly(C)/ Schizophyllan Complex Observed by AFM and SEM. H. Bae, S. W. Lee, M. Ikeda, M. Sano, S. Shinkai, K. Sakurai,. Carbohydr. Res., 339, 251-258(2004)

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  • Chemically Modified Polysaccharide Schizophyllan for Antisense Oligonucleotides Delivery to Enhance the Cellular Uptake Efficiency. T. Matsumoto, M. Numata, T. Anada, M. Mizu, K. Koumoto, K. Sakurai, T. Nagasaki, S. Shinkai. Biochim. Biophys. Acta, 1670, 91-104 (2004)

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  • Curdlan and Schizophyllan (β-1,3-Glucans) can Entrap Single-wall Carbon Nanotubes in Their Helical Superstructure. M. Numata, M. Asai, K. Kaneko, T. Hasegawa, N. Fujita, Y. Kitada, K. Sakurai, S. Shinkai, Chem. Lett., 33(3),232-233,(2004)

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  • Lactose-Appended Schizophyllan is a Potential Candidate as a Hepatocyte-Targetted Antisense Carrier. T. Hasegawa, M. Umeda, T. Matsumoto, M. Numata, M. Mizu, K. Koumoto, K. Sakurai, S. Shinkai. Chem. Commun., 382-383 (2004)

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  • Polysaccharide/Polynucleotide Complexes part 6:Complementary-Strand-Induced Release of Single-stranded DNA Bound in the Schizophyllan Complex. K. Koumoto, M. Mizu, K. Sakurai, T. Kunitake, S. Shinkai. Chemistry & Biodiversity, 1, (2004),520-529

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  • Enhancement of the Antisense Effect of Polysaccharide-Polynucleotide Complexes by Preventing the Antisense Oligonucleotide from Binding to Proteins in the Culture Medium. M. Mizu, K. Koumoto, T. Anada, R. Karinaga, T. Kimura, T. Nagasaki, S. Shinkai, K. Sakurai. Bull. Chem. Soc. Jpn., (2004)，77, 1101-1110  

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  • First Observation by Fluorescence Polarization of Complexation between mRNA and the Natural Polysaccharide Schizophyllan . R. Karinaga, M. Mizu, K. Koumoto, T. Anada, S. Shinkai, T. Kimura, K. Sakurai. Chemistry & Biodiversity, 1, 634-639 (2004)

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  • Removal of the Side-Chain Glucose Groups from Schizophyllan Improves the Thermal Stability of the Polycytidylic Acid Complexes under the Physiological Conditions. K. Koumoto, R. Karinaga, M. Mizu, T. Anada, K. Sakurai, T. Kunitake, S. Shinkai. Biopolymers, 75, 403-411(2004)

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  • Lactose-Appended Schizophyllan is a Potential Candidate as a Hepatocyte－Targetted Antisense Carrier. Teruaki Hasegawa, Mariko Umeda, Takahiro Matsumoto, Munenori Numata, Masami Mizu, Kazuya Koumoto, Kazuo Sakurai and Seiji Shinkai. Chem. Commun.,382-383(2004)

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  • Complementary-Strand-Induced Release of Single-Stranded DNA Bound in the Schizophyllan Complex. Kazuya Koumoto, Masami Mizu, Kazuo Sakurai, Toyoki Kunitake and Seiji Shinkai. Chemistry & Biodiversity,1, 520-529，(2004)

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  • Protection of Polynucleotides against Nuclease-Mediated Hydrolysis by Complexation with Schizophyllan. M. Mizu, K. Koumoto, T. Kimura, K. Sakurai, S. Shinkai. Biomaterials　 25, 3109-3116, (2004).

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  • A Polysaccharide Carrier for Immunostimulatory CpG DNAs to Enhance Cytokine Secretion. M. Mizu, K. Koumoto, T. Anada, T. Matsumoto, M. Numata, S. Shinkai, T. Nagasaki, K. Sakurai. J. Am. Chem. Soc.  126, 8372-8373, (2004).

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2004年

  • β-1,3-Glucan (Schizophyllan) Can Act as a One-Dimensional  Host for Creation of Novel Poly(aniline) Nanofiber Structures. Munenori Numata, Teruaki Hasegawa, Tomohisa Fujisawa, Kazuo Sakurai and Seiji Shinkai. Org. Lett., 6(24), 4447-4450,(2005)

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  • Schizophyllans Carrying Oligosaccharide-Appendages as Potential Candidates for Cell-Targeted Antisense Carrier. Teruaki Hasegawa, Tomohisa Fujisawa, Munenori Numata, Takahiro Matsumoto, Mariko Umeda, Ryouji Karinaga, Masami Mizu, Kazuya Koumoto, Taro Kimura, Shiro Okumura, Kazuo Sakurai and Seiji Shinkai. Organic and biomolecular chemistry, 2, 3091-3098(2004)

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  • Proposal of New Modification Technique for Linear Double-Stranded DNAs Using the Polysaccharide Schizopyllan. Takahisa Anada, Hideshi Matsunaga, Ryouji Karinaga, Kazuya Koumoto, Masami Mizu, Koji Nakano, Seiji Shinkai and Kazuo Sakurai. Bioorganic & Medicinal Chemistry Letters, 14, (2004),5655-5659

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  • Single-Walled Carbon Nanotubes Acquire a Specific Lectin-Affinity through Supramolecular Wrapping with Lactose-Appended Schizophyllan. Teruaki Hasegawa, Tomohisa Fujisawa, Munenori Numata, Mariko Umeda, Takahiro Matsumoto, Taro Kimura, Shiro Okumura, Kazuo Sakurai and Seiji Shinkai. Chem. Commun, 2150-2151,(2004)

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  • Rod-Like Architecture and Helicity of the Poly(C)/ Schizophyllan Complex Observed by AFM and SEM. H. Bae, S. W. Lee, M. Ikeda, M. Sano, S. Shinkai, K. Sakurai,. Carbohydr. Res., 339, 251-258(2004)

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  • Chemically Modified Polysaccharide Schizophyllan for Antisense Oligonucleotides Delivery to Enhance the Cellular Uptake Efficiency. T. Matsumoto, M. Numata, T. Anada, M. Mizu, K. Koumoto, K. Sakurai, T. Nagasaki, S. Shinkai. Biochim. Biophys. Acta, 1670, 91-104 (2004)

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  • Curdlan and Schizophyllan (β-1,3-Glucans) can Entrap Single-wall Carbon Nanotubes in Their Helical Superstructure. M. Numata, M. Asai, K. Kaneko, T. Hasegawa, N. Fujita, Y. Kitada, K. Sakurai, S. Shinkai, Chem. Lett., 33(3),232-233,(2004)

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  • Lactose-Appended Schizophyllan is a Potential Candidate as a Hepatocyte-Targetted Antisense Carrier. T. Hasegawa, M. Umeda, T. Matsumoto, M. Numata, M. Mizu, K. Koumoto, K. Sakurai, S. Shinkai. Chem. Commun., 382-383 (2004)

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  • Polysaccharide/Polynucleotide Complexes part 6:Complementary-Strand-Induced Release of Single-stranded DNA Bound in the Schizophyllan Complex. K. Koumoto, M. Mizu, K. Sakurai, T. Kunitake, S. Shinkai. Chemistry & Biodiversity, 1, (2004),520-529

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  • Enhancement of the Antisense Effect of Polysaccharide-Polynucleotide Complexes by Preventing the Antisense Oligonucleotide from Binding to Proteins in the Culture Medium. M. Mizu, K. Koumoto, T. Anada, R. Karinaga, T. Kimura, T. Nagasaki, S. Shinkai, K. Sakurai. Bull. Chem. Soc. Jpn., (2004)，77, 1101-1110  

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  • First Observation by Fluorescence Polarization of Complexation between mRNA and the Natural Polysaccharide Schizophyllan . R. Karinaga, M. Mizu, K. Koumoto, T. Anada, S. Shinkai, T. Kimura, K. Sakurai. Chemistry & Biodiversity, 1, 634-639 (2004)

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  • Removal of the Side-Chain Glucose Groups from Schizophyllan Improves the Thermal Stability of the Polycytidylic Acid Complexes under the Physiological Conditions. K. Koumoto, R. Karinaga, M. Mizu, T. Anada, K. Sakurai, T. Kunitake, S. Shinkai. Biopolymers, 75, 403-411(2004)

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  • Lactose-Appended Schizophyllan is a Potential Candidate as a Hepatocyte－Targetted Antisense Carrier. Teruaki Hasegawa, Mariko Umeda, Takahiro Matsumoto, Munenori Numata, Masami Mizu, Kazuya Koumoto, Kazuo Sakurai and Seiji Shinkai. Chem. Commun.,382-383(2004)

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  • Complementary-Strand-Induced Release of Single-Stranded DNA Bound in the Schizophyllan Complex. Kazuya Koumoto, Masami Mizu, Kazuo Sakurai, Toyoki Kunitake and Seiji Shinkai. Chemistry & Biodiversity,1, 520-529，(2004)

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  • Protection of Polynucleotides against Nuclease-Mediated Hydrolysis by Complexation with Schizophyllan. M. Mizu, K. Koumoto, T. Kimura, K. Sakurai, S. Shinkai. Biomaterials　 25, 3109-3116, (2004).

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  • A Polysaccharide Carrier for Immunostimulatory CpG DNAs to Enhance Cytokine Secretion. M. Mizu, K. Koumoto, T. Anada, T. Matsumoto, M. Numata, S. Shinkai, T. Nagasaki, K. Sakurai. J. Am. Chem. Soc.  126, 8372-8373, (2004).

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2003年

  • Mechanism of Thermally Induced Morphological Reorganization and Lamellar Orientation from the Herringbone Structure in Cross-Linked Polystyrene-Block-Polybutadiene-Block-Polystyrene Triblock Copolymers. S. Sakurai, S. Aida, S. Okamoto, K. Sakurai, S. Nomura. Macromolecules, 36(6), (2003)，1930-1939

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  • Mesomorphic Organization and Phase Diagram of Mixtures of Polymer Terminated with Ionic Group and Oppositely Charged Surfactant.　I.Akiba,Y.Jeong,K.Sakurai, Macromolecules, 36, (2003),8433-8439

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  • Microanalysis of Nucleic Acids Using the Limulus G Test. T. Anada, K. Koumoto, M. Mizu, R. Karinaga, K. Sakurai, S. Shinkai. Anal. Sci., 19, 1567-1568(2003)

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  • Polysaccharide-Polynucleotide Complexes (15): Thermal Stability of Schizophyllan (SPG)/poly(C) Triple Strands is Controllable by α-amino Acid Modification. M. Numata, T. Matsumoto, M. Umeda, K. Koumoto, K. Sakurai, S. Shinkai. Bioorg. Chem., 31,(2003)，163-171

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  • Polysaccharide-Polynucleotide complexes Part 17.　Solvent Effects on Conformational-Transition of polydeoxyadenylic Acid in the Complex with Schizophyllan. M. Mizu, K. Koumoto, T. Kimura, K. Sakurai, S. Shinkai. Polym. J., 35, 714-720，(2003)

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  • Polysaccharide-Polynucleotide Complexes Part 7. Hydrogen-Ion and Salt Concentration Dependence of Complexation between Schizophyllan and Single-Stranded Homo RNAs. K. Sakurai, R. Iguchi, M. Mizu, K. Koumoto, S. Shinkai. Bioorg. Chem., 31, 216-226(2003)

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  • Spherulite Formation from Microphase-Separated Lamellae in Semi-Crystalline Diblock Copolymer Comprising Polyethylene and Atactic Polypropylene Blocks. M. Ueda, K. Sakurai, S. Okamoto, D. J. Lohse, W. J. MacKnight, S. Shinkai, S. Sakurai, S. Nomura, Polymer, 44(2003), 6995-7005

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  • Supramolecular Structure of a Sugar-Appended Organogelator Explored with Synchrotron X-ray Small -Angle Scattering. K. Sakurai, Y. Jeong, K. Koumoto, A. Friggeri, O. Friggeri, O. Gronwald, S. Sakurai, S. Okamoto, K. Inoue, S. Shinkai. Langmuir 19, 8211-8217, (2003).

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2002年

  • Polysaccharide-Polynucleotide Complexes Ⅷ. Cation Induced Complex Formation Between Polyuridylic Acid and Schizophyllan. K. Sakurai, R. Iguchi, K. Koumoto, T. Kimura, M. Mizu, Y. Hisaeda, S. Shinkai. Biopolymers, 65, 1-9，(2002)

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  • Some Anomalies in Pressure-Induced Ordering of Glassy Spheres in a Rubbery Matrix of a Microphase-Separated Triblock Copolymers. S. Sakurai, S. Aida, T. Tamura, T. Kota, S. Okamoto, K. Sakurai, N. Tanaka, S. Kunugi, S. Nomura. Polymer, 43,(2002), 1959-1962

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  • Polysaccharide-Polynucleotide Complexes Part 12: Enhanced Affinity for Various Polynucleotide Chains by Site-Specific Chemical Modification of Schizophyllan. K. Koumoto, T. Kimura, M. Mizu, T. Kunitake, K. Sakurai, S. Shinkai. J. Chem. Soc, Perkin Trans. 1, 2477-2484(2002)

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  • Polysaccharide-Polynucleotide Interaction(Ⅺ);Novel Separation System of RNAs by Using Schizophyllan-Appended Column. T. Kimura, K. Koumoto, M. Mizu, K. Sakurai, S. Shinkai. Chem Lett., 1240-1241(2002)

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  • Novel DNA-Polysaccharide Triple Helix and its Application to a Gene Carrier. K. Sakurai, K. Koumoto, M. Mizu, S. Shinkai. Am. Chem. Soc. Polym. Prep., 43, 691-692，(2002)

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  • Chemical Modification of Curdlan: Characteristic Complexation with Polynucleotides by Control of The Molecular Weight. K. Koumoto, K. Sakurai, S. Shinkai, T. Kunitake. Am. Chem. Soc. Polym. Prep., 43,721-723，(2002)

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  • Self-Organized Structures of Hydrogen Bonded Poly(4-vinylphenol)-Tertiary Amino Lipid Mixtures. I.Akiba, K. Sakurai. e-Polymers, 53, (2002),1-6

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2001年

  • Complementary polynucleotide mimic behavior of a Natural polysaccharide: Schizophyllan in the Macromolecular Complex with a Single stranded RNA: Poly(C). K. Sakurai, M. Mizu, S. Shinkai. Biomacromolecules, 2, 641-650，(2001)

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  • Thermally Induced Conformational-Transition of Polydeoxyadenosine in the Complex with Schizophyllan and the Base-Length Dependence of Its Stability. M. Mizu, T. Kimura, K. Koumoto, K. Sakurai, S. Shinkai. Chem. Commun., 429-430(2001)

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  • Structural Analysis on Aggregates of Graft Copolymers Containing Tryptophan in Aqueous Media and Efficiency of Drug Release　Structure and properties of polymer materials． S. Okamoto, T. Hanai, F. Yamauchi, K. Nagata, S. Sakurai, K. Sakurai, E. Nakanishi. Material Science Research International, 7, 219-224，(2001)

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  • A Hexagonally Organizes Elemental Supramolecular Structure of a Sugar-Appended Organogelator  Observed by Synchrotron X-Ray Source (SPring-8). K. Sakurai, T. Kimura, O. Gronwald, K. Inoue, S. Shinkai. Chem. Lett.,(2001)，746-747

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  • Further Evidence for the Gelation    Ability-Structure Correlation in Suger-Based Gelators. O.Gronwald, K. Sakurai, R. Luboradzki, T. Kimura, S. Shinkai. Carbohydrate Res., 331,(2001), 307-318

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  • Synchrotron Small Angle X-ray Scattering from Organogels. Part 1. Changes in Molecular Assemblies of Cholesterol Gelators during Gel-Sol transition. K. Sakurai, Y. Ono, J. H. Jung, S. Okamoto, S. Sakurai, S. Shinkai. J. Chem.Soc., Perkin Trans.2,(2001),108-112

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  • Novel DNA-Polysaccharide Triple Helixes and Their Application to a Gene Carrier. K. Sakurai, S. Shinkai. J. Inclusion Phenomena and macrocyclic chemistry, 41(1-4)，173-178，(2001)

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  • Chemical Modification of Schizophyllan by Introduction of a Cationic Charge into the Side Chain which Enhances the Thermal Stability of Schizophyllan-Poly(C) Complexes. K. Koumoto, T. Kimura, M. Mizu, K. Sakurai, S. Shinkai. Chem. Commun.,1962-1963(2001)

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  • Chemical Modification of Curdlan to Induce an Interaction with Poly(C). K. Koumoto, T. Kimura, H. Kobayashi, K. Sakurai, S. Shinkai. Chem. Lett., 908-909(2001)

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  • Polysaccharide-Polynucleotide Complexes(Ⅳ): Antihydrolysis Effect of the Schizophyllan/Poly(C) Complex and the Cmplex Dissociation Induced by Amines. K. Koumoto, T. Kimura, K. Sakurai, S. Shinkai. Bioorg. Chem., 29, 178-185，(2001)

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